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Seaport Therapeutics, Inc.

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Seaport Therapeutics, Inc.

SPTX·NASDAQ·Life Sciences·CIK 0002042347

Seaport Therapeutics, Inc. operates as a clinical-stage biopharmaceutical company focused on developing new neuropsychiatric medicines. The company creates therapeutic candidates for conditions like depression and anxiety disorders. Its proprietary Glyph technology platform is central to its development efforts. This platform is designed to improve oral bioavailability, bypass first-pass metabolism, and reduce liver enzyme elevations, hepatotoxicity, and other side effects. All therapeutic candidates currently in development utilize this Glyph platform, with research and development activities specifically targeting neuropsychiatric medicines. Seaport Therapeutics, Inc. serves clinicians and key opinion leaders within the healthcare and neuropsychiatric medicine sectors. The company was founded in 2024 and is headquartered in Boston, Massachusetts.

Seaport Therapeutics, Inc. (NASDAQ:SPTX) is a publicly traded company in the Life Sciences sector. Wiseek has independently scored 12 items for SPTX at importance 7 or higher on its 1–10 market-impact scale. Its most recent item scored 7 or higher is dated 2026-09-09, rated 7/10. Across its 12 most recent items scored 7 or higher, the top rating is 9/10, with 10 rated 8 or above. Recent SEC coverage for SPTX spans 10-Q, 8-K, SCHEDULE 13D, 4.

Recent high-impact activity:

  • Seaport's GlyphAllo Shows No Driving Impairment in Phase 1, Boosting MDD Program
  • Seaport Therapeutics Q2 2026: Cash Runway Extended to 2029, Pipeline Advances
  • Seaport Therapeutics Q2 2026: $427M Cash, Pipeline Progress, and $260M Upsized IPO
  • Seaport Therapeutics Q2 Cash Surges to $427M, Pipeline Advances with Multiple Data Readouts Ahead
  • Seaport Therapeutics Reports Q1 Results, Confirms IPO Proceeds Extend Cash Runway into 2029

Short Interest & Short Volume

20.69 days to cover

FINRA reported short interest of 3,148,881 shares in SPTX as of the September 15, 2026 settlement, a 0.1% decrease from the prior period — about 20.7 days to cover at its recent average daily volume. On October 2, 2026, 90.8% of SPTX volume reported to FINRA trade-reporting facilities was marked short.

Short interest (bi-monthly positions)3,148,881 shares as of September 15, 2026
Change vs prior period▼ 0.1%
Days to cover20.69 at avg daily volume of 152,218
Daily short volume (FINRA facilities)90.8% of 73,942 shares on October 2, 2026
5-day average short volume74.7%

Daily short sale volume covers trades reported to FINRA trade-reporting facilities and is not the same as short interest (bi-monthly reported positions). Source: FINRA — FINRA is the owner and source of this short interest and short sale volume data; it may not be redistributed.

Dilution Risk

Low risk

Filing-implied dilution signals for SPTX, detected from its recent SEC filings · based on capital-structure filings through 2026-05-01.

1 recent capital raise

Initial Public Offering Priced · Significant Capital Raised

⚠ A more recent filing has been published for this ticker since this signal was computed; it may not yet be reflected — see the filings below.

A filing-implied signal, not a realized share count. How Wiseek tracks dilution →

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$18.42
52-week range · as of 2026-08-03 $14.85 – $22.98
Market cap
$986.03M
Volume
258.7K (1.0× avg)
3-mo avg 249.2K
Live data · 2026-10-05 04:06 UTC · Market overnight

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feed SPTX - Latest Insights

SPTX
Sep 09, 2026, 1:13 PM EDT
Source: BusinessWire
Importance Score:
7
Price at Filing: $22.99
Real-time Price: $18.42 info
Change: -$4.56 (-20%) info
Market Cap: $986.033M info
SPTX
Aug 03, 2026, 7:11 AM EDT
Filing Type: 10-Q
Importance Score:
8
Price at Filing: $20.46
Real-time Price: $18.42 info
Change: -$2.04 (-10%) info
Market Cap: $986.033M info
SPTX
Aug 03, 2026, 7:03 AM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $20.46
Real-time Price: $18.42 info
Change: -$2.04 (-10%) info
Market Cap: $986.033M info
SPTX
Aug 03, 2026, 7:00 AM EDT
Source: Dow Jones Newswires
Importance Score:
8
Price at Filing: $20.46
Real-time Price: $18.42 info
Change: -$2.04 (-10%) info
Market Cap: $986.033M info
SPTX
Jun 08, 2026, 7:15 AM EDT
Filing Type: 10-Q
Importance Score:
9
Price at Filing: $16.44
Real-time Price: $18.42 info
Change: +$1.98 (+12%) info
Market Cap: $986.033M info
SPTX
Jun 08, 2026, 7:11 AM EDT
Filing Type: 8-K
Importance Score:
9
Price at Filing: $16.44
Real-time Price: $18.42 info
Change: +$1.98 (+12%) info
Market Cap: $986.033M info
SPTX
Jun 08, 2026, 7:05 AM EDT
Source: Dow Jones Newswires
Importance Score:
9
Price at Filing: $16.44
Real-time Price: $18.42 info
Change: +$1.98 (+12%) info
Market Cap: $986.033M info
SPTX
May 11, 2026, 7:54 PM EDT
Filing Type: SCHEDULE 13D
Importance Score:
8
Price at Filing: $15.25
Real-time Price: $18.42 info
Change: +$3.17 (+21%) info
Market Cap: $986.033M info
SPTX
May 06, 2026, 4:26 PM EDT
Filing Type: SCHEDULE 13D
Importance Score:
9
Price at Filing: $16.00
Real-time Price: $18.42 info
Change: +$2.42 (+15%) info
Market Cap: $986.033M info
SPTX
May 04, 2026, 6:02 PM EDT
Filing Type: 4
Importance Score:
9
Price at Filing: $16.70
Real-time Price: $18.42 info
Change: +$1.72 (+10%) info
Market Cap: $986.033M info
SPTX
May 01, 2026, 5:31 PM EDT
Filing Type: 424B4
Importance Score:
9
Price at Filing: $19.78
Real-time Price: $18.42 info
Change: -$1.36 (-7%) info
Market Cap: $986.033M info
SPTX
Apr 30, 2026, 9:58 PM EDT
Source: Dow Jones Newswires
Importance Score:
9
Price at Filing: N/A
Real-time Price: $18.42 info
Change: N/A info
Market Cap: $986.033M info
Research tools: Filing Impact Index Dilution Tracker Split Calendar Open Datasets