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SEPN
NASDAQ Life Sciences

RA Capital Files to Sell $36M of Septerna Shares

Arie Shkolnikov · Analysis by Wiseek AI
More coverage: Biotech Stocks · Healthcare
Sentiment info
Negative
Importance info
7
Price
$48.19
Mkt Cap
$2.249B
52W Low
$10.616
52W High
$51.1
52W Position info
354% above low
Off High info
5.7% below high
Rel. Volume info
2.9× avg
Market data snapshot near publication time

SEPN has more than doubled off its 52-week low of $10.616 on elevated volume (2.9× avg).

Summary

RA Capital Nexus Fund III, L.P. filed a Form 144 to sell 746,500 shares of Septerna, Inc. common stock, valued at approximately $35.97 million. This is a significant proposed sale from a major institutional holder, representing about 1.6% of outstanding shares.


Key Events · Ownership and Investor Activity · SEPN

  • RA Capital Files $36M Sale

    RA Capital Nexus Fund III, L.P. filed a Form 144 to sell 746,500 shares of Septerna common stock, with an aggregate market value of $35,973,835.

  • Significant Institutional Selling

    The proposed sale represents approximately 1.6% of Septerna's 46,676,947 outstanding shares, a substantial position reduction by a major institutional holder.

  • Cluster of Selling Activity

    This filing follows a same-day Form 144 from Third Rock Ventures V, L.P. for $7.5 million, indicating coordinated institutional selling pressure.

  • 10b5-1 Plan Context

    The sale is being executed under a pre-existing 10b5-1 trading plan, which may reduce the informational content of the sale but still creates supply overhang.


Analysis · SEPN · Life Sciences

A substantial proposed sale from a major institutional holder is on the table: RA Capital Nexus Fund III, L.P. has filed a Form 144 to sell 746,500 shares of Septerna, Inc. common stock, valued at approximately $35.97 million based on the filing's aggregate market value. This represents about 1.6% of the company's outstanding shares. The filing comes on the same day as another Form 144 from Third Rock Ventures V, L.P. for $7.5 million, indicating a cluster of institutional selling activity. While the sale is under a pre-existing 10b5-1 plan, the size and timing may pressure the stock price.

At the time of this filing, SEPN was trading at $48.19 on NASDAQ in the Life Sciences sector, with a market capitalization of approximately $2.2B. The 52-week trading range was $10.62 to $51.10. This filing was assessed with negative market sentiment and an importance score of 7 out of 10.

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SEPN - Latest Insights

SEPN
Jun 22, 2026, 4:16 PM EDT
Filing Type: 144
Importance Score:
7
Price at Filing: $34.85
Real-time Price: $48.19 info
Change: +$13.34 (+38%) info
Market Cap: $2.249B info
SEPN
May 11, 2026, 4:08 PM EDT
Filing Type: 10-Q
Importance Score:
8
Price at Filing: $23.57
Real-time Price: $48.19 info
Change: +$24.62 (+104%) info
Market Cap: $2.249B info
SEPN
May 11, 2026, 4:05 PM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $23.57
Real-time Price: $48.19 info
Change: +$24.62 (+104%) info
Market Cap: $2.249B info
SEPN
Apr 13, 2026, 8:30 AM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $23.09
Real-time Price: $48.19 info
Change: +$25.10 (+109%) info
Market Cap: $2.249B info
SEPN
Apr 13, 2026, 8:00 AM EDT
Source: GlobeNewswire
Importance Score:
7
Price at Filing: $23.09
Real-time Price: $48.19 info
Change: +$25.10 (+109%) info
Market Cap: $2.249B info