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Prelude Therapeutics Inc

corporate_fare Company Profile

Prelude Therapeutics Inc

PRLD·NASDAQ·Life Sciences·CIK 0001678660

Prelude Therapeutics Incorporated is a precision oncology company focused on developing new cancer medicines for patients with limited treatment options. The company, founded in 2016, uses its expertise in cancer biology, medicinal chemistry, and clinical development to identify biological targets and create new chemical entities (NCEs) for clinical trials. Prelude has received multiple investigational new drug application (IND) clearances from the U.S. Food and Drug Administration (FDA) and has advanced several programs into clinical trials. Prelude's pipeline includes diverse programs such as kinases, targeted protein degraders, and precision antibody drug conjugates. The company is also collaborating with AbCellera Biologics, Inc. on an early-stage discovery program involving potent degraders as payloads for novel antibodies targeting tumor-specific antigens. Additionally, Prelude has other proprietary programs in various stages of preclinical development. The company aims to address diseases with high unmet medical needs by developing highly potent and specific agents against clinically validated targets, utilizing advances in new therapeutic modalities like targeted protein degradation.

Prelude Therapeutics Inc (NASDAQ:PRLD) is a publicly traded company in the Life Sciences sector. Wiseek has independently scored 22 items for PRLD at importance 7 or higher on its 1–10 market-impact scale. Its most recent item scored 7 or higher is dated 2026-10-13, rated 7/10. Across its 20 most recent items scored 7 or higher, the top rating is 9/10, with 13 rated 8 or above. Recent SEC coverage for PRLD spans 8-K, 10-Q, SCHEDULE 13D/A, 4.

Recent high-impact activity:

  • Prelude Partners with Lilly to Test KAT6A Degrader in Breast Cancer Combos
  • FDA Clears Prelude Therapeutics to Begin Phase 1 Trial of PRT13722 in HR+ Breast Cancer
  • FDA Clears Prelude's First-in-Class Oral KAT6A Degrader for Phase 1
  • Prelude Therapeutics Narrows Q2 Loss, Extends Cash Runway into 2028
  • Prelude Therapeutics Extends Cash Runway to Mid-2027 with $85.5M Offering & Reduced Burn

Financial Snapshot

Fiscal year ended December 31, 2025
Revenue
$12.14M
Net Income
-$99.5M
Diluted EPS
-$1.29
Op. Cash Flow
-$56.3M
Free Cash Flow
-$56.37M
Operating Income
-$104.57M
Cash & Equivalents
$35.26M
Debt / Equity
0.00×
Net Margin
-8.20×
Shares Outstanding
76.96M sh
Source: 10-K · filed 2026-03-10 · accession 0001193125-26-099428

Short Interest & Short Volume

11.47 days to cover

FINRA reported short interest of 5,097,463 shares in PRLD as of the October 15, 2026 settlement, a 11.4% increase from the prior period — about 11.5 days to cover at its recent average daily volume. On November 6, 2026, 80.5% of PRLD volume reported to FINRA trade-reporting facilities was marked short.

Short interest (bi-monthly positions)5,097,463 shares as of October 15, 2026
Change vs prior period▲ 11.4%
Days to cover11.47 at avg daily volume of 444,224
Daily short volume (FINRA facilities)80.5% of 50,788 shares on November 6, 2026
5-day average short volume71.0%

Daily short sale volume covers trades reported to FINRA trade-reporting facilities and is not the same as short interest (bi-monthly reported positions). Source: FINRA — FINRA is the owner and source of this short interest and short sale volume data; it may not be redistributed.

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$3.6
52-week range · as of 2026-09-10 $0.9807 – $6.83
Market cap
$287.29M
Volume
140.5K (0.3× avg)
3-mo avg 425.8K
Live data · 2026-11-07 12:25 UTC · Market closed

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feed PRLD - Latest Insights

PRLD
Oct 13, 2026, 7:01 AM EDT
Source: GlobeNewswire
Importance Score:
7
Price at Filing: $3.84
Real-time Price: $3.60 info
Change: -$0.240 (-6%) info
Market Cap: $287.293M info
PRLD
Sep 10, 2026, 7:29 AM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $5.15
Real-time Price: $3.60 info
Change: -$1.55 (-30%) info
Market Cap: $287.293M info
PRLD
Sep 10, 2026, 7:01 AM EDT
Source: GlobeNewswire
Importance Score:
7
Price at Filing: $5.40
Real-time Price: $3.60 info
Change: -$1.80 (-33%) info
Market Cap: $287.293M info
PRLD
Aug 11, 2026, 8:05 AM EDT
Filing Type: 10-Q
Importance Score:
7
Price at Filing: $4.99
Real-time Price: $3.60 info
Change: -$1.39 (-28%) info
Market Cap: $287.293M info
PRLD
May 12, 2026, 7:19 AM EDT
Filing Type: 10-Q
Importance Score:
8
Price at Filing: $4.98
Real-time Price: $3.60 info
Change: -$1.38 (-28%) info
Market Cap: $287.293M info
PRLD
May 12, 2026, 7:13 AM EDT
Source: Reuters
Importance Score:
8
Price at Filing: $4.92
Real-time Price: $3.60 info
Change: -$1.32 (-27%) info
Market Cap: $287.293M info
PRLD
May 12, 2026, 7:11 AM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $4.92
Real-time Price: $3.60 info
Change: -$1.32 (-27%) info
Market Cap: $287.293M info
PRLD
Apr 23, 2026, 8:42 PM EDT
Filing Type: SCHEDULE 13D/A
Importance Score:
8
Price at Filing: $4.80
Real-time Price: $3.60 info
Change: -$1.20 (-25%) info
Market Cap: $287.293M info
PRLD
Apr 23, 2026, 6:50 PM EDT
Filing Type: 4
Importance Score:
9
Price at Filing: $4.71
Real-time Price: $3.60 info
Change: -$1.11 (-24%) info
Market Cap: $287.293M info
PRLD
Apr 23, 2026, 6:48 PM EDT
Filing Type: 4
Importance Score:
9
Price at Filing: $4.71
Real-time Price: $3.60 info
Change: -$1.11 (-24%) info
Market Cap: $287.293M info
PRLD
Apr 22, 2026, 4:22 PM EDT
Filing Type: SCHEDULE 13D/A
Importance Score:
8
Price at Filing: $4.45
Real-time Price: $3.60 info
Change: -$0.8515 (-19%) info
Market Cap: $287.293M info
PRLD
Apr 20, 2026, 7:04 PM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $4.53
Real-time Price: $3.60 info
Change: -$0.930 (-21%) info
Market Cap: $287.293M info
PRLD
Apr 20, 2026, 6:44 PM EDT
Filing Type: 424B5
Importance Score:
8
Price at Filing: $4.53
Real-time Price: $3.60 info
Change: -$0.930 (-21%) info
Market Cap: $287.293M info
PRLD
Apr 20, 2026, 6:30 AM EDT
Source: GlobeNewswire
Importance Score:
9
Price at Filing: $4.90
Real-time Price: $3.60 info
Change: -$1.30 (-27%) info
Market Cap: $287.293M info
PRLD
Apr 20, 2026, 6:16 AM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $4.50
Real-time Price: $3.60 info
Change: -$0.900 (-20%) info
Market Cap: $287.293M info
PRLD
Apr 15, 2026, 7:41 AM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $4.32
Real-time Price: $3.60 info
Change: -$0.720 (-17%) info
Market Cap: $287.293M info
PRLD
Mar 12, 2026, 4:18 PM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $3.31
Real-time Price: $3.60 info
Change: +$0.290 (+9%) info
Market Cap: $287.293M info
PRLD
Mar 12, 2026, 4:16 PM EDT
Filing Type: 424B5
Importance Score:
7
Price at Filing: $3.22
Real-time Price: $3.60 info
Change: +$0.380 (+12%) info
Market Cap: $287.293M info
PRLD
Mar 10, 2026, 8:24 AM EDT
Filing Type: 10-K
Importance Score:
9
Price at Filing: $2.97
Real-time Price: $3.60 info
Change: +$0.6296 (+21%) info
Market Cap: $287.293M info
PRLD
Mar 10, 2026, 8:17 AM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $2.97
Real-time Price: $3.60 info
Change: +$0.6296 (+21%) info
Market Cap: $287.293M info
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