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Ionis Pharmaceuticals, Inc.

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Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSEDI for the treatment of ATTRv-PN in adults; and WAYLIVRA for treatment for FCS and familial partial lipodystrophy. It also develops products under Phase 3 clinical trials, such as Olezarsen for patients with hypertriglyceridemia (SHTG) and cardiovascular disease (CVD); Donidalorsen for patients with hereditary angioedema; and Zilganerse, a potential treatment for people with genetically confirmed Alexander disease, as well as ION582 that has completed Phase 2 clinical trial for the potential treatment of AS, a rare genetic neurological disease. In addition, the company develops Eplontersen to degrade mutant and wild-type TTR mRNA through binding to the TTR mRNA; Pelacarsen to inhibit the production of apolipoprotein(a) in the liver to offer a direct approach for reducing lipoprotein(a); Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus; Sefaxersen to reduce the production of complement factor B and lower activation of the alternative complement pathway; and Ulefnersen to reduce the production of the fused in sarcoma, as well as other mid-stage pipeline investigational medicines. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with GSK, AstraZeneca, Novartis, and Roche, as well as with Metagenomi. The company was incorporated in 1989 and is headquartered in Carlsbad, California.

Exchange: NASDAQSector: Life Sciences

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Apr 29, 2026, 2:33 PM EDT
Filing Type: 10-Q
Importance Score:
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Apr 29, 2026, 7:16 AM EDT
Source: Reuters
Importance Score:
9
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Apr 29, 2026, 7:00 AM EDT
Filing Type: 8-K
Importance Score:
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Apr 28, 2026, 3:14 AM EDT
Source: Reuters
Importance Score:
9
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Apr 23, 2026, 4:22 PM EDT
Filing Type: DEFA14A
Importance Score:
8
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Apr 23, 2026, 4:21 PM EDT
Filing Type: DEF 14A
Importance Score:
7
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Apr 21, 2026, 7:00 AM EDT
Filing Type: 8-K
Importance Score:
8
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Feb 26, 2026, 4:25 PM EST
Filing Type: 10-K
Importance Score:
9
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Feb 25, 2026, 7:00 AM EST
Filing Type: 8-K
Importance Score:
7
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Feb 06, 2026, 4:09 PM EST
Filing Type: 144
Importance Score:
8
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Feb 02, 2026, 8:51 PM EST
Filing Type: 4
Importance Score:
7
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Jan 12, 2026, 7:00 AM EST
Filing Type: 8-K
Importance Score:
8
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Jan 07, 2026, 6:02 AM EST
Filing Type: 8-K
Importance Score:
9