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Castle Biosciences Inc

corporate_fare Company Profile

Castle Biosciences Inc

CSTL·NASDAQ·Industrial Applications And Services·CIK 0001447362

Castle Biosciences is a molecular diagnostics company that provides innovative test solutions to assist clinicians in diagnosing and treating dermatologic cancers, Barrett's esophagus (BE), atopic dermatitis (AD), and uveal melanoma (UM). Since its inception in 2008, the company has focused on transforming disease management. Its testing solutions are designed to provide personalized information to inform clinical care decisions. For core tissue-based tests, Castle Biosciences uses multi-analyte assays with algorithmic analysis (MAAA) to characterize a patient's biology and generate clinically actionable information, which can guide treatment and patient management decisions, including potential responsiveness to therapy and disease diagnosis. The company's portfolio includes tests for cancers or precancerous diagnoses in dermatology, gastroenterology, and ophthalmology, and a test to guide systemic treatment decisions for patients with moderate-to-severe AD. The clinical validity and utility of its test portfolio are supported by approximately 158 peer-reviewed articles. Commercially available tests include DecisionDx-Melanoma, DecisionDx-SCC, and MyPath Melanoma in Dermatology; TissueCypher in Gastroenterology; and DecisionDx-UM in Ophthalmology. The AdvanceAD-Tx test commenced a limited launch in November 2025.

Castle Biosciences Inc (NASDAQ:CSTL) is a publicly traded company in the Industrial Applications And Services sector. Wiseek has independently scored 10 items for CSTL at importance 7 or higher on its 1–10 market-impact scale. Its most recent item scored 7 or higher is dated 2026-07-31, rated 7/10. Across its 10 most recent items scored 7 or higher, the top rating is 8/10, with 6 rated 8 or above. Recent SEC coverage for CSTL spans 10-Q, 8-K, DEF 14A, 10-K.

Recent high-impact activity:

  • Castle Biosciences' AdvanceAD-Tx Shows 97.8% Concordance in Atopic Dermatitis Study
  • Castle Biosciences Crushes Q2 Revenue, Lifts 2026 Outlook
  • Q2 2026 Revenue Surges 20.1%, YTD Net Loss Narrows, Liquidity Strong Amidst Raised Guidance
  • Castle Biosciences Smashes Q2 Revenue, Lifts 2026 Guidance to $365–375M
  • Castle Biosciences Reports Improved Q1 Net Loss and Strong Test Volume Growth

Financial Snapshot

Fiscal year ended December 31, 2025
Revenue
$344.23M
Net Income
-$24.16M
Diluted EPS
-$0.83
Op. Cash Flow
$64.35M
Free Cash Flow
$28.33M
Gross Profit
$273.2M
Operating Income
-$42.81M
Cash & Equivalents
$116.73M
Total Debt
$10.06M
Debt / Equity
0.02×
Net Margin
-7.0%
Shares Outstanding
29.69M sh
Source: 10-K · filed 2026-02-26 · accession 0001628280-26-012272

Short Interest & Short Volume

7.36 days to cover

FINRA reported short interest of 1,899,369 shares in CSTL as of the September 15, 2026 settlement, a 3.9% decrease from the prior period — about 7.4 days to cover at its recent average daily volume. On October 2, 2026, 67.5% of CSTL volume reported to FINRA trade-reporting facilities was marked short.

Short interest (bi-monthly positions)1,899,369 shares as of September 15, 2026
Change vs prior period▼ 3.9%
Days to cover7.36 at avg daily volume of 257,937
Daily short volume (FINRA facilities)67.5% of 52,071 shares on October 2, 2026
5-day average short volume52.3%

Daily short sale volume covers trades reported to FINRA trade-reporting facilities and is not the same as short interest (bi-monthly reported positions). Source: FINRA — FINRA is the owner and source of this short interest and short sale volume data; it may not be redistributed.

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$35.56
52-week range · as of 2026-07-30 $14.59 – $44.28
Market cap
$1.09B
Volume
167.7K (0.5× avg)
3-mo avg 358.1K
Live data · 2026-10-05 04:25 UTC · Market overnight

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feed CSTL - Latest Insights

CSTL
Jul 31, 2026, 3:15 AM EDT
Source: Wiseek News
Importance Score:
7
Price at Filing: $28.65
Real-time Price: $35.56 info
Change: +$6.91 (+24%) info
Market Cap: $1.086B info
CSTL
Jul 30, 2026, 4:15 PM EDT
Source: Reuters
Importance Score:
8
Price at Filing: $27.99
Real-time Price: $35.56 info
Change: +$7.57 (+27%) info
Market Cap: $1.086B info
CSTL
Jul 30, 2026, 4:09 PM EDT
Filing Type: 10-Q
Importance Score:
8
Price at Filing: $28.48
Real-time Price: $35.56 info
Change: +$7.08 (+25%) info
Market Cap: $1.086B info
CSTL
Jul 30, 2026, 4:06 PM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $28.83
Real-time Price: $35.56 info
Change: +$6.73 (+23%) info
Market Cap: $1.086B info
CSTL
May 06, 2026, 4:09 PM EDT
Filing Type: 10-Q
Importance Score:
7
Price at Filing: $24.60
Real-time Price: $35.56 info
Change: +$10.96 (+45%) info
Market Cap: $1.086B info
CSTL
May 06, 2026, 4:07 PM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $24.75
Real-time Price: $35.56 info
Change: +$10.81 (+44%) info
Market Cap: $1.086B info
CSTL
Apr 08, 2026, 10:13 AM EDT
Filing Type: DEF 14A
Importance Score:
7
Price at Filing: $25.57
Real-time Price: $35.56 info
Change: +$10.00 (+39%) info
Market Cap: $1.086B info
CSTL
Mar 13, 2026, 11:02 AM EDT
Source: GlobeNewswire
Importance Score:
8
Price at Filing: $25.44
Real-time Price: $35.56 info
Change: +$10.12 (+40%) info
Market Cap: $1.086B info
CSTL
Feb 26, 2026, 4:09 PM EST
Filing Type: 10-K
Importance Score:
8
Price at Filing: $31.88
Real-time Price: $35.56 info
Change: +$3.68 (+12%) info
Market Cap: $1.086B info
CSTL
Jan 13, 2026, 9:43 AM EST
Filing Type: 8-K
Importance Score:
8
Price at Filing: $39.64
Real-time Price: $35.56 info
Change: -$4.08 (-10%) info
Market Cap: $1.086B info
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