Cocrystal Pharma, Inc.

Cocrystal Pharma, Inc. is a clinical-stage biotechnology company focused on discovering and developing new antiviral treatments for serious and/or chronic viral diseases. The company uses unique structure-based technologies and expertise to create antiviral drugs. These technologies aim to produce small molecule therapeutics that are safe, effective, and easy to administer. Cocrystal has identified promising antiviral compounds at discovery, preclinical, and clinical stages. These compounds target unmet medical needs caused by RNA viruses, including influenza virus, norovirus, coronaviruses (such as SARS-CoV-2 & MERS-CoV), respiratory virus infections, and hepatitis C virus ("HCV") infections. The company operates as a single business entity. Cocrystal's technology involves developing small molecule antiviral therapeutics that inhibit the essential replication function of RNA viruses. The company's goals include treating and preventing influenza virus, norovirus, and coronavirus infections by discovering and developing direct-acting antiviral drug candidates that target required steps in the viral replication process. To achieve this, Cocrystal uses a proprietary platform that includes computational chemistry, medicinal chemistry, X-ray crystallography, and extensive know-how. The company determines the structures of cocrystals containing inhibitors bound to the viral enzyme or protein to guide its structure-based drug design. It also uses advanced computational methods to screen and design product candidates, utilizing proprietary high-resolution cocrystal structural information. In designing candidates, Cocrystal aims to anticipate and prevent potential viral mutations that could lead to resistance. The company seeks to develop drugs that are effective against both the virus and its possible mutants, with reduced off-target interactions to minimize undesirable clinical side effects. This approach requires extensive knowledge of viruses, drug targets, structural biology, pharmacology, virology, and enzymology.