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CRESCENT BIOPHARMA, INC.

corporate_fare Company Profile

CRESCENT BIOPHARMA, INC.

CBIO·NASDAQ·Life Sciences·CIK 0001253689

GlycoMimetics, Inc. is a clinical-stage biotechnology company focused on developing therapies for people with cancer. The company was incorporated in Delaware in 2003 and, on June 16, 2025, changed its jurisdiction of incorporation to the Cayman Islands. It operates through two distinct strategies to build its portfolio. First, it is developing CR-001, a PD-1 x VEGF bispecific antibody designed to bind both the PD-1 immune checkpoint and Vascular Endothelial Growth Factor. This product has the potential to replace pembrolizumab, marketed as Keytruda®, as a foundational immuno-oncology treatment. A global Phase 1/2 trial of CR-001, known as the ASCEND trial, was initiated in February 2026. Second, the company is building a portfolio of antibody drug conjugates (ADCs). The company intends to combine CR-001 and ADC therapies. It anticipates initiating CR-002 and CR-003 monotherapy clinical trials in 2026, as well as the first ADC combination trial with CR-001 in the same year.

CRESCENT BIOPHARMA, INC. (NASDAQ:CBIO) is a publicly traded company in the Life Sciences sector. Wiseek has independently scored 18 items for CBIO at importance 7 or higher on its 1–10 market-impact scale. Its most recent item scored 7 or higher is dated 2026-07-30, rated 7/10. Across its 18 most recent items scored 7 or higher, the top rating is 9/10, with 11 rated 8 or above. Recent SEC coverage for CBIO spans 10-Q, 8-K, SCHEDULE 13D/A, 424B5.

Recent high-impact activity:

  • Crescent Biopharma Q2 Loss Narrows to $24.8M; Pro Forma Cash Hits $305M, Runway Into 2028
  • Crescent Biopharma Extends Cash Runway to H2 2028 with Q2 2026 Results, Maps Out Multiple 2027 Data Catalysts
  • Crescent Biopharma Posts $24.8M Q2 Loss, Cash Runway Extended to H2 2028; Key Data Readouts in 2027
  • Fairmount Funds reveals $20M commitment in Crescent Biopharma's $125M offering, lifting its stake to 16.5%
  • Crescent Biopharma Closes $143.7M Offering, Full Overallotment Exercised

Financial Snapshot

Fiscal year ended December 31, 2025
Revenue
$10.84M
Net Income
-$153.94M
Op. Cash Flow
-$71.53M
Free Cash Flow
-$72.45M
Operating Income
-$152.63M
Cash & Equivalents
$213.19M
Debt / Equity
0.00×
Net Margin
-14.20×
Shares Outstanding
27.56M sh
Source: 10-K · filed 2026-02-26 · accession 0001628280-26-011983

Short Interest & Short Volume

8.51 days to cover

FINRA reported short interest of 3,407,158 shares in CBIO as of the September 15, 2026 settlement, a 7.4% increase from the prior period — about 8.5 days to cover at its recent average daily volume. On October 2, 2026, 74.9% of CBIO volume reported to FINRA trade-reporting facilities was marked short.

Short interest (bi-monthly positions)3,407,158 shares as of September 15, 2026
Change vs prior period▲ 7.4%
Days to cover8.51 at avg daily volume of 400,407
Daily short volume (FINRA facilities)74.9% of 75,677 shares on October 2, 2026
5-day average short volume66.7%

Daily short sale volume covers trades reported to FINRA trade-reporting facilities and is not the same as short interest (bi-monthly reported positions). Source: FINRA — FINRA is the owner and source of this short interest and short sale volume data; it may not be redistributed.

Dilution Risk

Low risk

Filing-implied dilution signals for CBIO, detected from its recent SEC filings · based on capital-structure filings through 2026-07-30.

3 recent capital raisesATM program1 shelf registration

Offering Priced at $14.50/Share · Net Proceeds of ~$115.9 Million

A filing-implied signal, not a realized share count. How Wiseek tracks dilution →

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$14.32
52-week range · as of 2026-07-30 $8.72 – $27.41
Market cap
$531.9M
Volume
283.3K (0.6× avg)
3-mo avg 452.7K
Live data · 2026-10-04 11:13 UTC · Market closed

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feed CBIO - Latest Insights

CBIO
Jul 30, 2026, 9:25 AM EDT
Filing Type: 10-Q
Importance Score:
7
Price at Filing: $14.77
Real-time Price: $14.32 info
Change: -$0.450 (-3%) info
Market Cap: $531.901M info
CBIO
Jul 30, 2026, 7:36 AM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $14.77
Real-time Price: $14.32 info
Change: -$0.450 (-3%) info
Market Cap: $531.901M info
CBIO
Jul 30, 2026, 7:35 AM EDT
Source: GlobeNewswire
Importance Score:
7
Price at Filing: $14.77
Real-time Price: $14.32 info
Change: -$0.450 (-3%) info
Market Cap: $531.901M info
CBIO
Jul 20, 2026, 5:30 PM EDT
Filing Type: SCHEDULE 13D/A
Importance Score:
7
Price at Filing: $15.05
Real-time Price: $14.32 info
Change: -$0.730 (-5%) info
Market Cap: $531.901M info
CBIO
Jul 16, 2026, 4:01 PM EDT
Source: GlobeNewswire
Importance Score:
7
Price at Filing: $15.11
Real-time Price: $14.32 info
Change: -$0.790 (-5%) info
Market Cap: $531.901M info
CBIO
Jul 15, 2026, 4:56 PM EDT
Filing Type: 424B5
Importance Score:
8
Price at Filing: $15.44
Real-time Price: $14.32 info
Change: -$1.12 (-7%) info
Market Cap: $531.901M info
CBIO
Jul 14, 2026, 9:45 PM EDT
Source: GlobeNewswire
Importance Score:
8
Price at Filing: $15.31
Real-time Price: $14.32 info
Change: -$0.985 (-6%) info
Market Cap: $531.901M info
CBIO
Jul 14, 2026, 4:01 PM EDT
Filing Type: 424B5
Importance Score:
8
Price at Filing: $14.00
Real-time Price: $14.32 info
Change: +$0.320 (+2%) info
Market Cap: $531.901M info
CBIO
Jul 14, 2026, 4:01 PM EDT
Source: GlobeNewswire
Importance Score:
8
Price at Filing: $14.55
Real-time Price: $14.32 info
Change: -$0.230 (-2%) info
Market Cap: $531.901M info
CBIO
Jul 01, 2026, 4:16 PM EDT
Filing Type: S-3
Importance Score:
9
Price at Filing: $17.08
Real-time Price: $14.32 info
Change: -$2.76 (-16%) info
Market Cap: $531.901M info
CBIO
Apr 29, 2026, 4:28 PM EDT
Filing Type: 424B3
Importance Score:
8
Price at Filing: $20.94
Real-time Price: $14.32 info
Change: -$6.62 (-32%) info
Market Cap: $531.901M info
CBIO
Apr 29, 2026, 4:15 PM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $20.94
Real-time Price: $14.32 info
Change: -$6.62 (-32%) info
Market Cap: $531.901M info
CBIO
Apr 29, 2026, 4:06 PM EDT
Filing Type: 10-Q
Importance Score:
7
Price at Filing: $20.94
Real-time Price: $14.32 info
Change: -$6.62 (-32%) info
Market Cap: $531.901M info
CBIO
Apr 21, 2026, 4:15 PM EDT
Filing Type: DEF 14A
Importance Score:
9
Price at Filing: $24.61
Real-time Price: $14.32 info
Change: -$10.29 (-42%) info
Market Cap: $531.901M info
CBIO
Mar 17, 2026, 4:00 PM EDT
Filing Type: 424B3
Importance Score:
9
Price at Filing: $11.10
Real-time Price: $14.32 info
Change: +$3.22 (+29%) info
Market Cap: $531.901M info
CBIO
Feb 26, 2026, 7:27 AM EST
Filing Type: 10-K
Importance Score:
9
Price at Filing: $12.49
Real-time Price: $14.32 info
Change: +$1.83 (+15%) info
Market Cap: $531.901M info
CBIO
Jan 15, 2026, 5:04 PM EST
Filing Type: 424B3
Importance Score:
9
Price at Filing: $13.55
Real-time Price: $14.32 info
Change: +$0.775 (+6%) info
Market Cap: $531.901M info
CBIO
Jan 07, 2026, 5:08 PM EST
Filing Type: S-1
Importance Score:
9
Price at Filing: $10.80
Real-time Price: $14.32 info
Change: +$3.52 (+33%) info
Market Cap: $531.901M info
Research tools: Filing Impact Index Dilution Tracker Split Calendar Open Datasets