Carlsmed, Inc.

aprevo is a commercial-stage medical technology company that develops AI-enabled personalized spine surgery solutions. The company aims to make its aprevo Technology Platform the standard of care for spine fusion surgery, with a mission to improve outcomes and decrease healthcare costs for spine surgery. The aprevo Technology Platform was designed to address limitations in traditional lumbar and cervical spine fusion surgery, aiming to optimize patient outcomes and reduce the need for revision surgeries. The technology uses AI-enabled, outcome-based algorithms to create personalized surgical plans for spine fusion. The aprevo surgical kit provided to customers contains interbody implants designed for a custom vertebral fit for each patient's specific pathology and bone topography, along with single-use surgical instruments. The aprevo Technology Platform assists surgeons in achieving proper spinal alignment for patients with degenerative disc disease ("DDD"), which can improve clinical outcomes and reduce the likelihood of revision surgeries. aprevo currently markets the aprevo Technology Platform for lumbar and cervical spine fusion surgeries. DDD involves the progressive breakdown of spinal discs, which provide mobility and shock absorption between vertebrae. This disease occurs naturally with age and can be accelerated by factors such as injury, repetitive loading, obesity, or genetic predisposition. Adult spinal deformity ("ASD") is a more severe form of DDD, characterized by systematic structural abnormalities and/or abnormal curvature of the spine, often affecting multiple levels. These conditions frequently lead to loss of disc height and spine function, chronic pain, disability, and other chronic spinal pathologies. Surgical intervention may become necessary when these conditions progress and patients experience debilitating pain or disabilities. One study estimated the overall prevalence of diagnosed DDD was 27.3% for individuals over the age of 65, increasing with age. Non-surgical interventions are typically the initial treatment for DDD, focusing on managing symptoms and slowing disease progression without invasive procedures. Surgical interventions may be required when non-surgical treatments fail to alleviate debilitating symptoms or disabilities.