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BioCryst Pharmaceuticals, Inc.

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BioCryst Pharmaceuticals, Inc.

BCRX·NASDAQ·Life Sciences·CIK 0000882796

We are a global biotechnology company focused on developing and commercializing medicines for hereditary angioedema ("HAE") and other rare diseases. The company has a commercial infrastructure for ORLADEYO, an oral, once-daily therapy for the prevention of HAE attacks, which was discovered and developed internally. This commercial platform is leveraged to commercialize a pipeline of potential first-in-class or best-in-class oral small molecule and injectable protein therapeutics for rare diseases, pursued through internal discovery and strategic business development. The company's commercially available or actively developed molecules include: - ORLADEYO® (berotralstat), an Oral Serine Protease Inhibitor Targeting Kallikrein, approved in the United States and multiple global markets as a once-daily oral capsule treatment for Hereditary Angioedema. A once-daily oral pellets treatment for patients 2 to <12 years of age is approved in the United States for Hereditary Angioedema. - Navenibart (STAR-0215), a Monoclonal Antibody Plasma Kallikrein Inhibitor, in Phase 3 for Hereditary Angioedema. - BCX17725, a Protein Therapeutic, in Phase 1 for Netherton Syndrome. - Avoralstat, an Ocular Plasma Kallikrein Inhibitor, in Phase 1 for Diabetic Macular Edema. - STAR-0310, a Monoclonal Antibody OX40 Antagonist, in Phase 1a for Atopic Dermatitis. - RAPIVAB® (peramivir injection), an Intravenous Neuraminidase Inhibitor, approved in the United States, Australia & Canada for Acute Uncomplicated Influenza. - RAPIACTA® (peramivir injection), an Intravenous Neuraminidase Inhibitor, for Uncomplicated... (text truncated). The company is also pursuing certain pre-clinical medicines for other rare disease targets.

BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) is a publicly traded company in the Life Sciences sector. Wiseek has independently scored 16 items for BCRX at importance 7 or higher on its 1–10 market-impact scale. Its most recent item scored 7 or higher is dated 2026-08-25, rated 8/10. Across its 16 most recent items scored 7 or higher, the top rating is 9/10, with 12 rated 8 or above. Recent SEC coverage for BCRX spans 8-K, 8-K/A, 10-Q, 10-K.

Recent high-impact activity:

  • Japan Approves ORLADEYO for Pediatric HAE, Expanding Market
  • BioCryst Q2: ORLADEYO Revenue Reaches $158M, Operating Profit Hits $98M, Guidance Lifted
  • BioCryst Puts $6.2–$7.5M Price Tag on Discovery Shutdown Severance
  • BioCryst Restructures R&D, Closes Facility, Lowers OpEx Guidance by $30M
  • BioCryst Cuts $30M in OpEx, Pivots R&D to External Innovation, Closes Facility

Financial Snapshot

Fiscal year ended December 31, 2025
Revenue
$874.84M
Net Income
$263.86M
Diluted EPS
$1.21
Op. Cash Flow
$347.37M
Free Cash Flow
$344.9M
Gross Profit
$855.76M
Operating Income
$340.99M
Cash & Equivalents
$89.74M
Total Debt
$0
Debt / Equity
0.00×
Net Margin
30.2%
Shares Outstanding
213.06M sh
Source: 10-K · filed 2026-02-26 · accession 0001628280-26-012240

Short Interest & Short Volume

7.29 days to cover

FINRA reported short interest of 34,868,460 shares in BCRX as of the September 15, 2026 settlement, a 2.4% increase from the prior period — about 7.3 days to cover at its recent average daily volume. On October 2, 2026, 24.7% of BCRX volume reported to FINRA trade-reporting facilities was marked short.

Short interest (bi-monthly positions)34,868,460 shares as of September 15, 2026
Change vs prior period▲ 2.4%
Days to cover7.29 at avg daily volume of 4,780,741
Daily short volume (FINRA facilities)24.7% of 2,814,232 shares on October 2, 2026
5-day average short volume31.2%

Daily short sale volume covers trades reported to FINRA trade-reporting facilities and is not the same as short interest (bi-monthly reported positions). Source: FINRA — FINRA is the owner and source of this short interest and short sale volume data; it may not be redistributed.

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$8.15 -0.02% today
52-week range · as of 2026-08-05 $6 – $11.22
Market cap
$2.09B
Volume
6.1M (1.3× avg)
3-mo avg 4.8M
Live data · 2026-10-05 04:25 UTC · Market overnight

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feed BCRX - Latest Insights

BCRX
Aug 25, 2026, 7:01 AM EDT
Source: GlobeNewswire
Importance Score:
8
Price at Filing: $9.65
Real-time Price: $8.15 info
Change: -$1.50 (-16%) info
Market Cap: $2.088B info
BCRX
Aug 05, 2026, 7:02 AM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $9.65
Real-time Price: $8.15 info
Change: -$1.50 (-16%) info
Market Cap: $2.088B info
BCRX
Aug 04, 2026, 7:01 AM EDT
Filing Type: 8-K/A
Importance Score:
7
Price at Filing: $8.89
Real-time Price: $8.15 info
Change: -$0.740 (-8%) info
Market Cap: $2.088B info
BCRX
Jun 29, 2026, 7:06 AM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $9.43
Real-time Price: $8.15 info
Change: -$1.28 (-14%) info
Market Cap: $2.088B info
BCRX
Jun 29, 2026, 7:00 AM EDT
Source: GlobeNewswire
Importance Score:
8
Price at Filing: $9.49
Real-time Price: $8.15 info
Change: -$1.34 (-14%) info
Market Cap: $2.088B info
BCRX
Jun 12, 2026, 4:10 PM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $8.70
Real-time Price: $8.15 info
Change: -$0.550 (-6%) info
Market Cap: $2.088B info
BCRX
May 06, 2026, 4:06 PM EDT
Filing Type: 10-Q
Importance Score:
8
Price at Filing: $8.77
Real-time Price: $8.15 info
Change: -$0.620 (-7%) info
Market Cap: $2.088B info
BCRX
May 06, 2026, 7:08 AM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $9.00
Real-time Price: $8.15 info
Change: -$0.850 (-9%) info
Market Cap: $2.088B info
BCRX
May 06, 2026, 7:00 AM EDT
Source: Dow Jones Newswires
Importance Score:
9
Price at Filing: $9.49
Real-time Price: $8.15 info
Change: -$1.34 (-14%) info
Market Cap: $2.088B info
BCRX
May 04, 2026, 7:06 AM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $9.28
Real-time Price: $8.15 info
Change: -$1.13 (-12%) info
Market Cap: $2.088B info
BCRX
May 04, 2026, 7:00 AM EDT
Source: GlobeNewswire
Importance Score:
8
Price at Filing: $9.28
Real-time Price: $8.15 info
Change: -$1.13 (-12%) info
Market Cap: $2.088B info
BCRX
Feb 26, 2026, 4:03 PM EST
Filing Type: 10-K
Importance Score:
9
Price at Filing: $7.90
Real-time Price: $8.15 info
Change: +$0.250 (+3%) info
Market Cap: $2.088B info
BCRX
Feb 26, 2026, 7:19 AM EST
Filing Type: 8-K
Importance Score:
9
Price at Filing: $7.83
Real-time Price: $8.15 info
Change: +$0.320 (+4%) info
Market Cap: $2.088B info
BCRX
Jan 23, 2026, 4:30 PM EST
Filing Type: 8-K
Importance Score:
9
Price at Filing: $6.70
Real-time Price: $8.15 info
Change: +$1.45 (+22%) info
Market Cap: $2.088B info
BCRX
Jan 12, 2026, 4:28 PM EST
Filing Type: 8-K
Importance Score:
7
Price at Filing: $7.23
Real-time Price: $8.15 info
Change: +$0.920 (+13%) info
Market Cap: $2.088B info
BCRX
Jan 09, 2026, 7:01 AM EST
Filing Type: 8-K
Importance Score:
8
Price at Filing: $7.62
Real-time Price: $8.15 info
Change: +$0.530 (+7%) info
Market Cap: $2.088B info
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