SenesTech, Inc.

The company develops and commercializes products for managing animal pest populations using fertility control and population management strategies. Its current products, ContraPest, Evolve Rat, and Evolve Mouse, focus on rat and mouse populations. Rodents are significant economic pests, threatening human and animal health, food security, and infrastructure globally. They are reservoir hosts for at least 60 zoonotic diseases, posing risks to public health, safety, and agriculture by affecting crops, livestock, stored grain, and farm workers. Diseases like leptospirosis and salmonellosis directly impact livestock reproductive efficiency, contaminate feed, and increase liability for agricultural operators. Rats destroy at least 20% of the global stored food supply annually through consumption and contamination. In the United States alone, rats cause over $27 billion in annual damage to public and private infrastructure by burrowing and gnawing on electrical wiring, insulation, fire-proofing systems, and equipment. Rodents reproduce rapidly, and even intensive lethal control efforts are often undermined by quick population rebound due to high fecundity, early sexual maturity, and density-dependent compensation. Urbanization, climate variability, and aging infrastructure contribute to accelerated rodent population growth and increased infestation pressures globally, including in major metropolitan areas, leading to higher economic costs and public health risks. While lethal methods like traps and rodenticides have been dominant, increasing evidence of non-target secondary poisoning and bioaccumulation has raised environmental and regulatory concerns, driving demand for ecologically-friendly alternatives.