Molecular Partners Initiates Lead Radio-DARPin Phase 1/2a Study, Reports Strong Cash Runway to 2028

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This filing provides a comprehensive positive update on Molecular Partners' clinical pipeline and financial health. The initiation of the Phase 1/2a trial for MP0712, a lead Radio-DARPin, marks a critical advancement for the company's targeted alpha therapy platform. Further progress in the MP0317 and MP0533 trials, with patient dosing ongoing and data updates expected, demonstrates broad pipeline execution. Crucially, the reported cash and cash equivalents of CHF 93.1 million, providing a runway until 2028, significantly de-risks the company from near-term financing needs and potential dilution, allowing it to focus on advancing its clinical programs. Investors should monitor the upcoming data readouts and the nomination of new candidates as key catalysts.

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• Lead Radio-DARPin Enters Clinic

  The Phase 1/2a study for MP0712, a lead Radio-DARPin targeting DLL3 for small cell lung cancer (SCLC), has been initiated in the US, with first patient dosing expected in Q1 2026 and initial data anticipated in 2026.

• Robust Financial Outlook

  The company reported CHF 93.1 million in cash and cash equivalents as of December 31, 2025, which is projected to fund operating expenses and capital expenditure requirements until 2028.

• Pipeline Advancement

  The Phase 2 investigator-initiated trial for MP0317 (cholangiocarcinoma) is now open with patient dosing ongoing, and the Phase 1/2a trial for MP0533 (AML) is progressing, with an update on its clinical development path planned for H1 2026.

• J.P. Morgan Presentation

  Molecular Partners will present these clinical development updates and anticipated milestones at the 44th Annual J.P. Morgan Healthcare Conference on January 15, 2026.

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This filing provides a comprehensive positive update on Molecular Partners' clinical pipeline and financial health. The initiation of the Phase 1/2a trial for MP0712, a lead Radio-DARPin, marks a critical advancement for the company's targeted alpha therapy platform. Further progress in the MP0317 and MP0533 trials, with patient dosing ongoing and data updates expected, demonstrates broad pipeline execution. Crucially, the reported cash and cash equivalents of CHF 93.1 million, providing a runway until 2028, significantly de-risks the company from near-term financing needs and potential dilution, allowing it to focus on advancing its clinical programs. Investors should monitor the upcoming data readouts and the nomination of new candidates as key catalysts.