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SYRE
NASDAQ Life Sciences

Director-Affiliated Fund Files Intent to Sell $399.6M in Spyre Therapeutics Stock

Analysis by Wiseek AI
Sentiment info
Negative
Importance info
9
Price
$86.5
Mkt Cap
$8.428B
52W Low
$14
52W High
$102.06
Market data snapshot near publication time

Summary

A director-affiliated institutional fund has filed a Form 144 indicating intent to sell approximately $399.6 million worth of Spyre Therapeutics common stock.


Key Events

  • Director-Affiliated Fund Files Intent to Sell

    Fairmount Healthcare Fund II L.P., an investment fund whose manager (Tomas Kiselak) is also a director of Spyre Therapeutics, has filed a Form 144 indicating intent to sell shares.

  • Proposed Sale of $399.6 Million

    The fund intends to sell 4,684,781 shares of common stock, with an approximate market value of $399,658,667. This represents about 4.7% of the company's current market capitalization.

  • Follows Positive News and Capital Raise

    This intent to sell comes after Spyre Therapeutics reported positive Phase 2 clinical trial data for SPY001 and SPY002 in April and June, and successfully completed a $435.3 million public offering in April.


Analysis

Fairmount Healthcare Fund II L.P., an institutional investor with a director on Spyre Therapeutics' board, has filed an intent to sell a substantial block of shares. The proposed sale of nearly $400 million represents a significant portion of the company's market value and follows recent positive clinical trial data and a successful public offering. This large-scale insider intent to sell could signal profit-taking or a re-evaluation of the investment thesis by a key stakeholder, contributing to a broader trend of insider distribution.

At the time of this filing, SYRE was trading at $86.50 on NASDAQ in the Life Sciences sector, with a market capitalization of approximately $8.4B. The 52-week trading range was $14.00 to $102.06. This filing was assessed with negative market sentiment and an importance score of 9 out of 10.

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SYRE - Latest Insights

SYRE
Jun 23, 2026, 9:57 PM EDT
Filing Type: 144
Importance Score:
9
Price at Filing: $86.50
Real-time Price: $86.50 info
Change: $0 (0%) info
Market Cap: $8.428B info
SYRE
Jun 23, 2026, 9:56 PM EDT
Filing Type: 4
Importance Score:
8
Price at Filing: $86.50
Real-time Price: $86.50 info
Change: $0 (0%) info
Market Cap: $8.428B info
SYRE
Jun 23, 2026, 9:45 PM EDT
Filing Type: SCHEDULE 13D/A
Importance Score:
9
Price at Filing: $86.50
Real-time Price: $86.50 info
Change: $0 (0%) info
Market Cap: $8.428B info
SYRE
Jun 15, 2026, 8:03 AM EDT
Source: Wiseek News
Importance Score:
9
Price at Filing: $82.50
Real-time Price: $86.50 info
Change: +$4.00 (+5%) info
Market Cap: $8.428B info
SYRE
Jun 15, 2026, 8:01 AM EDT
Filing Type: 8-K
Importance Score:
9
Price at Filing: $82.50
Real-time Price: $86.50 info
Change: +$4.00 (+5%) info
Market Cap: $8.428B info
SYRE
Jun 03, 2026, 8:00 AM EDT
Source: GlobeNewswire
Importance Score:
7
Price at Filing: $69.67
Real-time Price: $86.50 info
Change: +$16.83 (+24%) info
Market Cap: $8.428B info
SYRE
Jun 01, 2026, 4:01 PM EDT
Filing Type: 8-K
Importance Score:
7
Price at Filing: $70.54
Real-time Price: $86.50 info
Change: +$15.96 (+23%) info
Market Cap: $8.428B info
SYRE
May 05, 2026, 8:00 AM EDT
Filing Type: 10-Q
Importance Score:
9
Price at Filing: $68.13
Real-time Price: $86.50 info
Change: +$18.37 (+27%) info
Market Cap: $8.428B info
SYRE
Apr 16, 2026, 4:15 PM EDT
Filing Type: 8-K
Importance Score:
8
Price at Filing: $69.76
Real-time Price: $86.50 info
Change: +$16.74 (+24%) info
Market Cap: $8.428B info
SYRE
Apr 16, 2026, 4:15 PM EDT
Source: GlobeNewswire
Importance Score:
9
Price at Filing: $69.76
Real-time Price: $86.50 info
Change: +$16.74 (+24%) info
Market Cap: $8.428B info